• We have identified a molecule, CRC-001 specific to CRC. Our goal is to use this to diagnose and develop treatments against CRC.

• We believe CRC-001 is likely detected in the blood from metastatic CRC cells.

• Colorectal cancer is a common and potentially preventable form of cancer that arises from the lining of the colon or rectum, often developing slowly from precancerous polyps over many years, and is one of the leading causes of cancer-related death worldwide. However, outcomes are significantly improved with early detection through routine screening methods such as colonoscopy, stool-based tests, or imaging studies.

• Statistics highlight the significant burden of colorectal cancer and the impact of prevention and early detection. Among the top three most commonly diagnosed cancers, it is the leading cause of cancer-related death worldwide.

• In the United States, it is one of the most frequently diagnosed cancers in both men and women. Incidence rates increase sharply with age, which is why routine screening is recommended starting in mid-adulthood, though concerningly, rates have been rising among younger adults under 50. When detected early and confined to the colon or rectum, the five-year survival rate exceeds 90%, but this drops substantially once the cancer has spread to lymph nodes or distant organs. These statistics underscore the importance of screening, early diagnosis, and public health efforts aimed at reducing modifiable risk factors.